My first protein crystal structure

Here it is, guys. The structure is 2.4 Angstrom resolution, which is not too bad for a start. This happens to be a PWWP domain that recognizes methylated lysine containing peptides. The goal now is to design ligands on the basis of the small molecule fragment (you can see it) that has co-crystallized. I was talking to my PhD student Rebecca the other day and she is very keen to tackle this problem. Today I learned that another crystal might be sent out to the synchrotron soon. That will be awesome. Big-time thanks to Elena (who teaches me protein crystallography) and to Aiping Dong, who is the crystallography expert. He is amazing. I love chasing proteins!


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