Below is one of my favourite quotations and I hope you like it. I think that my recent experience with getting macrocycle crystals together with my students underscores the notion that, at some point, we just need to drastically increase the number of experiments we can run and analyze. Effectively, what Elena and I have been doing with protein crystal structures, can (and should) be applied to other molecules which are tricky to crystallize. We have shown that the SGC platform is adaptable to other scenarios and I will continue our work along these lines of screening. Dr. Paul Reider (Merck) told me once that at least 10% of a researcher’s work should be aimed at science that is not hypothesis-driven but is Edisonian. I concur: this is what we should do more of. Nature is just too complicated.