Cascade starts from a Mitsunobu…

Here is a very neat result from Jon Ellman’s lab at Yale. As part of a study documented in Org. Lett. (, an interesting observation was made: the intended nitrogen-driven Mitsunobu process did not take place. Instead, a cyclopropane has been formed:


Building on this observation, Andrade’s lab showed a really cool cascade process that ultimately enabled a short synthesis of (-) melotenine A ( I think the mechanism is really interesting. Cascade reactions rule!


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