Understanding the difference between necessity and sufficiency is supremely important in order to build solid arguments in science. While I am sure you all agree this to be the case, it is interesting how often we fall prey to fallacy if we disregard this fundamental distinction. Sadly, there are research projects that hinge on shaky grounds because it is often enticing to be selective about which parts of causal relationships to pursue and which to ignore. There are many examples I could quote, but none come close to the idea of enzyme mimicry, which is one of the most absurd and ludicrous notions. Time and again we see claims of simple systems that approach enzymatic efficiency. These ideas persist and, unless weeded out from the literature, confuse students who take sand castles for their face value. It happened with Atassi’s claims of cyclic peptide-based miniature enzymes in the 1990’s and it happened again more recently, when Ser-His was billed as an efficient catalyst with protease-like qualities. The truth is that the presence of catalytic groups in close proximity is necessary, but not sufficient for enzymatic activity. Stable and precise alignment of the said functionalities would make a catalyst, which is not achevable with small molecules. There is a nice recent Org. Lett. paper by Don Hilvert and Sam Gellman, which takes on Ser-His, goes through a number of control experiments, and delivers the lasting verdict (again): do not try to mimic enzymes.