Happy New Year, everyone! Lets kick 2017 by looking at what is up with dyotropic rearrangements. I mentioned them in the past, but still have trouble finding too many of these fascinating reactions in papers. Perhaps one of the reasons for this lack of occurrence is that substrates for dyotropic processes tend to be fairly complex. This naturally brings me to total synthesis, where the starting material complexity is a moot point. The example below comes from the lab of Professor Thomas Magauer. I met him last summer in Munich and became acquainted with his innovative program. Now that his paper dedicated to the synthesis of dictooxetane is out, you can also enjoy the rare case of a dyotropic process that has been put to good use here. In this case, an epoxide/oxetane system participates in a dyotropic rearrangement. As a result of the bond switch, the scaffold gets transformed into a tetrahydrofuran/oxetane, which represents a downhill process. Copper tetrafluoroborate was used as the Lewis acid to trigger this process.